Trademarked name: Solpadein
Dosage form:
tabletsCompound
Each tablet contains:
paracetamol 500 mg
codeine phosphate 8 mg
caffeine 30 mg.
Excipients: soluble starch, corn starch, povidone, potassium sorbate, microcrystalline cellulose, purified talc, stearic acid, magnesium stearate, ethanol (95%), demineralized water, hydroxypropyl methylcellulose, carmazin (E122)
Description: elongated white tablets in the form of capsules. On one side of the tablet there is a red “Solpadeine” marking.
Pharmacotherapeutic group:
analgesic non-narcotic agent.ATX code: N02BE51
Pharmacological properties:
Solpadein contains a combination of three active ingredients: paracetamol has an antipyretic, analgesic effect, caffeine has a tonic effect (reduces drowsiness and fatigue, increases mental and physical performance, increases heart rate, increases blood pressure in case of hypotension), enhances the antipyretic effect of the drug, codeine has analgesic effect and improves pain tolerance.Indications for use:
Solpadein is used in adults and children over 12 years of age with pain syndrome: headache, toothache, migraine, muscle and joint pain, neuralgia, painful menstruation, sciatica, sprains, sinusitis and sore throat. Solpadein is also used to reduce fever in adults and children over 12 years of age, with "colds", other infectious and inflammatory diseases and flu.Contraindications:
- Hypersensitivity to paracetamol, codeine, caffeine or any other ingredient of the drug;
- concomitant use of other paracetamol-containing agents
- severe abnormalities in liver or kidney function;
- blood diseases (thromocytopenia, anemia];
- genetic absence of glucose-6-phosphate dehydrogenase;
- glaucoma
- respiratory failure, conditions after traumatic brain injury, increased intracranial pressure
- arterial hypertension;
- period of pregnancy and breastfeeding;
- childhood(up to 12 years old)
Carefully- with Gilbert's syndrome (constitutional hyperbilirubinemia), congenital hyperbilirubinemia (Dubin-Johnson and Rotor), bronchial asthma, old age.
Method of administration and dosage:
The drug is administered orally after meals by adults and children over 16 years of age, 1-2 tablets 3-4 times a day at intervals of at least 4 hours. The maximum single dose is 2 tablets. Maximum daily dose 8 tablets. For children from 12 to 16 years old - 1 tablet 3-4 times a day, at intervals of at least 4 hours. The maximum daily dose is 4 tablets.The drug should not be taken for more than 5 days when prescribed as an anesthetic and more than 3 days as an antipyretic. The change in the dose and the interval between doses is determined by the doctor.
Side effect:
The drug is well tolerated in the recommended doses. Nausea, epigastric pain, allergic reactions ( skin rash, itching, urticaria, Quincke's edema). Very rarely - anemia, thrombocytopenia, methemoglobinemia. Rarely, palpitations, constipation, sleep disturbances, drowsiness, and dizziness may occur. With prolonged use in doses significantly exceeding the recommended ones, the likelihood of impaired liver and kidney function increases and monitoring of the blood picture is necessary. All side effects of the drug should be reported to the doctor.Overdose:
Symptoms: nausea, vomiting, stomach pain, sweating, pallor skin, tachycardia. With mild intoxication - ringing in the ears; severe intoxication - confusion, drowsiness, collapse, convulsions, bronchospasm, shortness of breath. If you suspect poisoning, you must immediately apply for medical help... Treatment: the victim should undergo gastric lavage, prescribe adsorbents (activated carbon) and consult a doctor.Interaction drugs:
The drug, when taken for a long time, enhances the effect indirect anticoagulants(warfarin and other coumarins), which increases the risk of bleeding Stimulants of microsomal oxidation in the liver (phenytoin, diphenin, ethanol, barbiturates, carbamazepine, flumecinol, rifampicin, zidovudine phenylbutazone and tricyclic active antidepressants) increase the possibility of the development of heavy hydroxylated with small overdoses. Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic effects. Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol. Reduces the effectiveness of uricosuric drugs. Caffeine accelerates the absorption of ergothamine. Codeine enhances the effects of hypnotics, analgesics and sedatives. Ethanol increases the half-life of paracetamol, increasing the risk of hepatotoxic effects.
Special instructions:
Before taking the drug, you should consult your doctor if:- You have asthma or other respiratory disease;
- You are taking antidepressants, drugs for nausea and vomiting, and those that lower blood cholesterol levels;
TO PREVENT LIVER TOXIC DAMAGE, PARACETAMOL SHOULD NOT BE COMBINED WITH ALCOHOLIC BEVERAGES. AND ALSO TAKE BY PERSONS LIKE CHRONIC ALCOHOL USE.
Solpadeine may cause drowsiness. In this case, when taking Solpadein, one should refrain from driving vehicles and engaging in potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions. Since the drug contains codeine, it should be borne in mind the possibility of developing addiction.
Release form:
Tablets.4, 5,6,8 or 12 tablets per blister (pvc / aluminum foil). 1 or 2 blisters of 5 or 6 tablets, or 1 blister of 8 tablets, or 1 blister of 12 tablets are packed in a cardboard box along with instructions for use.
1 or 2 blisters of 5 or 6 tablets joined together, or 1 blister of 8 tablets, or 1 blister of 4 tablets and 1 blister of 8 tablets each, packed in a plastic box-cover (PVC / aluminum) on which full text instructions for use, approved by the Ministry of Health of the Russian Federation
Best before date:
5 years Do not use after the expiration date stated on the package.Storage conditions:
Store at a temperature not exceeding 25 C, out of the reach of children.Conditions for dispensing from pharmacies:
Without recipe.Manufacturer:
GlaxoSmithKline Consumer Healthcare, manufactured by GlaxoSmithKline Dungarvan Limited, Ireland. GlaxoSmithKline Dungarvan Ltd., Knockbrack, Dungarvan. Co. Waterford., Ireland.GlaxoSmithKline Dungarvan Ltd., Knockbrak, Dungarvan, County Waterford. Ireland,
Address in Russia: 119180 Moscow, Yakimanskaya emb., 2
Another effective analgesic and antipyretic drug is Solpadein. It is a combination antipyretic containing a combination of three active ingredients - paracetamol, caffeine and codeine. The action of caffeine is to tone up, reduce fatigue and drowsiness. Caffeine increases both physical and mental performance, as well as blood pressure. Paracetamol has analgesic and antipyretic effects. Codeine works to reduce pain.
This drug can be taken as an antipyretic and anesthetic. This means that its dosage and treatment regimen will be individual. Do not forget that the correct treatment regimen can only be prescribed by the attending physician, depending on the specific painful condition. Solpadein tablets alone can be used as an anesthetic for five days, and as an antipyretic agent for no more than three days.
How to take Solpadein correctly?
- Adults and children over 16 years old can use this drug 1-2 tablets 3-4 times a day. The time interval between taking the pills is four hours. The maximum permissible daily dose of the drug is eight tablets, and a single dose is two tablets.
- Children, whose age ranges from 12 to 16 years old, can take Solpadein one tablet 3-4 times a day. The recommended time interval between taking them is four hours. The maximum allowable single dose is one tablet, the maximum daily dose is four tablets.
- Do not give this medicine to children under 12 years of age without first consulting a doctor.
Indications for use
The first thing to know about taking Solpadein is that it is prescribed only to adults and children who are over 12 years old. This medicine is intended to reduce the pain syndrome that can occur against the background of diseases such as sciatica, sinusitis, neuralgia, etc. In addition, this drug contributes to the almost complete disappearance of various types of pain, including toothache, menstrual pain, headache. Due to its presence in its composition, Solpadein reduces the patient's body temperature, therefore it is prescribed for colds, infectious diseases.
It is important to remember that use Solpadein during pregnancy is prohibited, therefore, the future mom, if she is worried about any strong pain or any other painful condition, you should definitely consult a doctor. A woman expecting a baby cannot drink pills on her own!
Abbott Nutrition Ltd SMITHKLINE BEECHAM CONSUMER HEALTHCARE SmithKline Beecham Liquides Industrie STERLING HEALTH Glaxo Wellcome GmbH & Co. Glaxo Wellcome Production GlaxoSmithKline GmbH & Co. KG / Heumann Pharma GmbH GlaxoSmithKline Dungarvan Ltd. GlaxoSmithKline Consumer Healthcare GlaxoSmithKline Consumer Healthker / Glaxo Welcom Pro GlaxoSmithKline Consumer Healthker / Dungarvan Limited Famar S.A.Country of origin
Greece Ireland Spain FranceProduct group
Pain medicationsCombined analgesic non-narcotic drug
Forms of issue
- 2 - strips (2) - cardboard boxes. 2 - strips (4) - cardboard boxes. 2 - strips (6) - cardboard boxes. 2 - strips (12) - cardboard boxes. 2 - strips (30) - cardboard boxes. 2 - laminated strips (6) - cardboard packs 2 - laminated strips 46) - cardboard packs. 6 - blisters (1) - cardboard boxes. 6 - blisters (2) - cardboard boxes. 12 - blisters (1) - cardboard boxes. 12 tabs in a blister (2), placed in cards. pack.
Description of the dosage form
- Hard gelatin capsules, size No. 0, with biconvex spherical ends, opaque, with a red to red-brown cap and a white body, with a black inscription "Solpadeine" printed on both sides of the capsule; the contents of the capsules are white amorphous powder with white tablets covered with a film-coated capsule-shaped shell with a flat edge. On one side of the tab, there is a sign in the form of a triangle or +. Tablets are white, capsule-shaped, elongated, marked with red "Solpadeine" on one side. Soluble tablets, white, flat, with a circumferentially cut edge and a score on one side. Soluble tablets, white, flat, beveled, smooth on one side and scored on the other.
pharmachologic effect
An analgesic-antipyretic combined composition, contains a combination of two active ingredients: paracetamol and caffeine. It has antipyretic and analgesic effects. Paracetamol blocks cyclooxygenase in the central nervous system, affecting the centers of pain and thermoregulation (in inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX), which explains the almost complete absence of the anti-inflammatory effect. The lack of influence on the synthesis of prostaglandins in peripheral tissues leads to the absence of a negative effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa. Caffeine stimulates the psychomotor centers of the brain, has an analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, and increases physical and mental performance.Pharmacokinetics
Data on the pharmacokinetics of the drug Solpadein Fast are not provided.Special conditions
Excessive consumption of tea and coffee is not recommended while taking the drug. this can lead to agitation, sleep disturbances, tachycardia, cardiac arrhythmias. In cases of long-term use in high doses, it is necessary to control the blood picture. To avoid toxic damage to the liver, patients taking Solpadein Fast should refrain from drinking alcohol. It is not recommended to prescribe the drug for chronic alcoholism. Patients with atopic bronchial asthma and hay fever have an increased risk of developing allergic reactions. For patients on a salt-free or low-salt diet, the sodium content of the tablet (427 mg) should be taken into account when calculating the daily salt intake. When conducting analyzes to determine uric acid and blood glucose levels should be told to the doctor about taking the drug. Solpadein Fast can change the results of athletes' doping control tests. The drug should be used with caution in case of fructose intolerance, since the drug contains sorbitol. Overdose In case of overdose, seek immediate medical attention, even if you feel well. Symptoms of a paracetamol overdose: nausea, vomiting, stomach pain, pallor of the skin, anorexia. After 1-2 days, signs of liver damage are determined. In severe cases, liver failure and coma develop. Treatment: make a gastric lavage, prescribe adsorbents (activated carbon), carry out symptomatic therapy.Compound
- 1 tab. paracetamol 500 mg codeine phosphate hemihydrate 8 mg caffeine 30 mg Excipients: soluble starch, corn starch, povidone, potassium sorbate, microcrystalline cellulose, purified talc, stearic acid, magnesium stearate, ethanol 95%, demineralized cellulose water (E12), E12 ... 1 tab. paracetamol 500 mg caffeine 65 mg 1 tab. paracetamol 500 mg codeine phosphate hemihydrate 8 mg caffeine 30 mg Excipients: sodium bicarbonate, sorbitol, sodium saccharin, sodium lauryl sulfate, citric acid anhydrous, sodium carbonate anhydrous, polyvidone, dimethicone. 1 tab. paracetamol 500 mg caffeine 65 mg paracetamol 500 mg caffeine 65 mg Excipients: sorbitol, sodium saccharinate, sodium bicarbonate, povidone, sodium lauryl sulfate, dimethicone, citric acid, sodium carbonate.
Solpadein indications for use
- Pain syndrome in adults and children over 12 years old, including: - headache; - toothache; - migraine; - pain in muscles and joints; - neuralgia; - painful menstruation; - with sciatica; - with sprains; - with sinusitis; - sore throat. To reduce elevated body temperature in adults and children over 12 years of age with colds, other infectious and inflammatory diseases and flu.
Solpadein contraindications
- - severe violations of liver or kidney function; - blood diseases (thrombocytopenia, anemia); - genetic absence of glucose-6-phosphate dehydrogenase; - glaucoma; - respiratory failure, conditions after traumatic brain injury, increased intracranial pressure; - arterial hypertension; - Simultaneous intake of other paracetamol-containing agents; - pregnancy; - the period of breastfeeding; - children's age (up to 12 years old); - increased individual sensitivity to paracetamol, codeine, caffeine or any other ingredient of the drug. The drug should be used with caution in Gilbert's syndrome (constitutional hyperbilirubinemia), congenital hyperbilirubinemia (Dubin-Johnson and Rotor), bronchial asthma, as well as in old age.
Solpadein side effects
- Allergic reactions: rash, itching, Quincke's edema. From the digestive system: dyspeptic disorders (including nausea, epigastric pain). From the hematopoietic system: rarely - leukopenia, thrombocytopenia, methemoglobinemia, agranulocytosis, hemolytic anemia... Others: sleep disturbance, tachycardia. In the recommended doses, the drug is usually well tolerated. With prolonged use in high doses, the likelihood of hepatotoxic action, nephrotoxic action and pancytopenia increases.
Drug interactions
When taken for a long time, the drug enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding. Enhances the action of MAO inhibitors. Barbiturates, phenytoin, ethanol, rifampicin, phenylbutazone, tricyclic antidepressants and other inducers of microsomal oxidation increase the production of hydroxylated active metabolites, causing the development of severe intoxication with small overdoses. Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxic effects. Under the influence of paracetamol, T1 / 2 of chloramphenicol increases 5 times. Caffeine accelerates the absorption of ergotamine. The simultaneous use of paracetamol and ethanol increases the risk of developing hepatotoxic effects and acute pancreatitis. Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol. The drug may reduce the effectiveness of uricosuric drugs.Overdose
Symptoms: nausea, vomiting, stomach pain, sweating, pallor of the skin, tachycardia; with mild intoxication - ringing in the ears; with severe intoxication - confusion, drowsiness, collapse, convulsions, bronchospasm, shortness of breath. Treatment: make a gastric lavage.Storage conditions
- keep away from children
- store in a dark place
Advertising has recently begun to frequently promote to the masses more and more new drugs. "Solpadein" also belongs to those. From what this drug, what are the indications and contraindications for its use, we will tell in the article.
About the drug
The remedy appeared in our pharmacies relatively recently. It comes in three forms: tablets, capsules and effervescent soluble tablets. Produced by the famous Spanish pharmaceutical company SmithKline Beach.
This drug belongs to the difference between the funds is as follows: "Solpadein" effervescent very quickly acts, which favorably stands out among other funds of a similar orientation.
Pleases a wide range of drug action. In his "jurisdiction" - the fight against headache, dental, postoperative and post-traumatic, Side effects and he has relatively few contraindications. The biggest disadvantage is perhaps the price of the product.
Compound
The effectiveness of the drug is due to its composition. However, Solpadein, the use of which is quite simple and convenient, does not contain any rare or unusual components. Before us complex preparation consisting of several components. The main active ingredient is paracetamol, familiar to us from childhood - an analgesic and antipyretic agent. Has a mild anti-inflammatory effect.
The second component of the "Solpadein" drug (from which it is, we will describe in more detail below) is caffeine. This substance is known for its stimulating effects on the nervous system. The positive effects include the effect on the production of adrenaline and dopamine (substances that can reduce pain), a beneficial, mobilizing effect on muscles.
Solpadein also contains a small amount of codeine phosphate, an analgesic narcotic substance with a strong analgesic effect.
All components together act on the central nervous system, eliminate spasm, and minimize pain and discomfort after injuries and surgeries.
Solpadein tablets. Instructions
The drug should be taken only as directed or after consulting a doctor.
The maximum daily dose for an adult is eight capsules. Application for more than three days must be discussed with a specialist.
The drug, depending on the form of release, is taken in capsules or dissolved in warm water, juice. With intense pain it is recommended to drink one to two capsules every four hours.
What does "Solpadein" help from?
Let's move on to the main question. From what, in what cases is it recommended to use "Solpadein" to relieve pain?
- Headaches of various etiologies (including migraines).
- Neuralgia, lumbago and sciatica.
- Back pain of any origin.
- Toothache (with inflammatory processes, during the treatment period, after tooth extraction and other manipulations in the oral cavity).
- Strong pain in the joints and muscles (with arthritis and arthrosis, trauma, inflammatory processes and in the postoperative period).
- Recurrent pain in women.
The tool is effective and fast-acting. But do not forget that its purpose of application is not treatment, but getting rid of pain. If they are so intense that the person needs a pain reliever, a doctor's consultation is necessary. "Solpadein" (effervescent tablets, capsules or regular tablets - choose the form with a specialist) will relieve you of discomfort, but not of the disease itself.
Indication for use
Most of the cases when the drug will help, we have listed above. Sometimes the remedy is mistakenly used for fever and fever. This is not entirely advisable, since in this case the usual "Paracetamol", which, most likely, is in every first-aid kit would do just fine. "Solpadein" from what helps it was considered.
Contraindications Who is not allowed "Solpadein"
The tool, like any other, has a number of contraindications. Among them are the following:
- You are not shown Solpadein if you have a history of an allergic reaction to opium analgesics.
- If there was a previous head injury and / or increased intracranial pressure.
- With severe violations of the kidneys and liver.
- Thrombosis and thrombophlebitis.
- Bronchial asthma or a tendency to bronchospasmodic conditions.
- Ailments of cardio-vascular system including heart failure and ischemic disease hearts.
- Diabetes mellitus and hyperthyroidism.
- Sleep disturbances, depression or nervous strain.
- Epilepsy or a tendency to this disease.
The drug is also contraindicated in pregnancy and lactation and in elderly patients.
It is unsafe to use "Solpadein" (effervescent tablets, the use of which, like capsules, can be harmful to health, should not be taken without a doctor's recommendation) with a single use of alcohol or alcoholism. Any amount of alcohol you drink is equally dangerous.
Special instructions. What you need to pay attention to
As we remember from the instructions presented above, in the composition of "Solpadein" there is a high dose of caffeine. This means that the drug will be contraindicated for ardent “coffee lovers” who cannot imagine their life without several cups of strong coffee a day. As you can imagine, the amount of caffeine in the human body, consuming a lot of this invigorating drink, is already quite high. Taking "Solpadein" in this case can cause a serious overdose of caffeine, the mildest consequences of which are insomnia, a feeling of unreasonable anxiety and depression.
Another note: do not forget that a significant amount of caffeine is found not only in coffee, but also in tea, including the green varieties of this drink.
It is unacceptable when taking "Solpadein" the use of any, even weak alcohol. It is also worth remembering that the drug contains a high dose of paracetamol, so it is not recommended to combine these drugs.
Side effects
As with any medication, side effects may occur when using the drug.
On the part of the cardiovascular system, these are tachycardia and arrhythmia; the gastrointestinal tract can react to the intake of "Solpadein" with nausea and urge to vomit, discomfort in the epigastric region, with prolonged use - constipation.
There is a likelihood of allergic reactions from the skin, such as itching, rash, urticaria, etc. In very rare cases, it is recorded. It should also be borne in mind that with prolonged use of the drug, its toxic effect on the liver increases. The consequences can be an increase in liver enzymes, severe vomiting, and a feeling of pain and heaviness in the right side. Treatment in these cases involves stopping the medication and eliminating the symptoms.
When using barbiturates (sedatives, the most famous of which are Valocordin, Nitrazepam) and Rifampicin, the effect on the liver increases significantly. You should be very careful when combining these drugs with the one we are considering.
Solpadein and cough
Another feature of the drug is that it can save you from severe cough... Codeine has a strong effect on cough centers and is able to arrest and stop severe bouts of residual cough after bronchitis or ARVI. However, it is worth remembering that the drug is by no means a panacea for cough treatment! It only removes unpleasant symptoms when urgently needed (for example, during a scheduled lecture or meeting). Treatment, however, should be prescribed by a doctor, based on the anamnesis and the tests received.
Solpadein is an analgesic drug that contains a combination of 3 main components: codeine, paracetamol and caffeine.
Codeine and paracetamol have analgesic, antipyretic effects. They help to improve pain tolerance. Caffeine reduces fatigue and increases physical stamina and mental alertness.
Compound
The drug is available in several forms: in the form of capsule and soluble tablets. It contains a mixture of 3 ingredients: paracetamol, codeine phosphate hemihydrate, as well as other auxiliary components: magnesium stearate, corn starch, stearic acid, ethanol, microcrystalline cellulose, povidone, potassium sorbate, carmazin and others.
Doctors recommend taking the drug orally after eating. The rules of treatment with this medication depend on the age of the person. Adults and children over 16 years old can drink 1 - 2 tablets 3 to 4 times a day. The interval between the use of tablets should not be 4 hours. In this case, the maximum permissible single dose is 2 tablets, and the daily dose is 8 tablets.
Children, whose ages range from 12 to 16 years old, should take 1 to 4 tablets per day. The maximum allowable single dosage is 1 tablet, and the daily dosage is 4 tablets.
What does Solpadein help from?
This drug is effective for painful sensations of various etiologies... It is recommended for children over the age of 12, as well as for adults with pain syndrome. Solpadein normalizes body temperature in case of pathologies of a cold, infectious and inflammatory nature.
Contraindications
Among the contraindications to the use of this medication are conditions such as:
- deficiency of glucose-6-phosphate dehydrogenase;
- respiratory failure;
- pregnancy and breastfeeding;
- elderly age;
- diseases of the circulatory system;
- glaucoma is a group of eye diseases characterized by an increase in intraocular pressure with the subsequent development of visual defects;
- high blood pressure;
- impaired functioning of the liver and kidneys;
- hypersensitivity to the ingredients present in the composition of this medication;
- bronchial asthma;
- children under 12 years of age.
Adverse Reactions
In medical practice, a small number of cases were recorded with the occurrence of adverse reactions against the background of the use of this drug. As a rule, a similar effect is manifested with improper treatment with Solpadein. Therefore, it is very important to take this medication strictly according to the instructions.
If this medication is misused, you may experience the following:
- skin rash;
- sleep disturbance;
- pain in the stomach;
- sweating;
- noise in ears;
- confused consciousness;
- dizziness;
- constipation;
- Quincke's edema;
- nausea;
- anemia;
- cardiopalmus;
- thrombocytopenia;
- cramps and other unpleasant symptoms.
If you feel unwell while taking this medication, stop using this medication, contact your doctors and, if necessary, wash your stomach and drink activated charcoal.
Best before date
This drug must be stored in a dark place out of the reach of children at a temperature not exceeding 25 ° C. The shelf life of a medicine depends on the form of its release and varies from 4 to 5 years.